‘Sure, that may be about correct. I seek for a physical comprehension of Organic methods in the base-up way. I think you might distinguish three traces of exploration in my team in the meanwhile. The main issues chromosome framework: How does one get a metre-extended DNA polymer folded and organised in this kind of microscopic mobile? We have produced visualisation approaches that allow for us to study how, by way of example, SMC proteins loop DNA (video on Youtube) to be able to Create up chromosomes.
Our group experiments bacterial mobile division and it is aiming to constitute a ‘base up biology’ in artificial cells that will autonomously divide. Our principal interest lies in mobile division, chromatin composition, and spatial Handle.
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2007, initially real-time detection of strand Trade in homologous recombination by RecA; discovery of a very low persistence length of ends of microtubules; and solved the system of biosensing with carbon nanotubes
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Instance (three) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim in the pore is highlighted in red, and also a 3D rendering in the motion with the DNA rod is displayed.
Length control of individual carbon nanotubes by nanostructuring with the scanning tunneling microscope
He also uncovered time https://www.ceesdekker.net to write down quite a few publications, send out almost forty thousand tweets and direct A prosperous study team at Delft College of Engineering. ‘It doesn’t experience like perform’, he suggests. ‘I’m just terribly curious.’
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Resolving the stage dimension in condensin-driven DNA loop extrusion identifies ATP binding as the step-generating process
Given that 2000 he moved to one-molecule biophysics and nanobiology, with analysis from studies of DNA loop extrusion and supercoiling to DNA translocation by nanopores. A lot more recently his exploration has focused on finding out chromatin structure and mobile division with bacteria on chip, even though he is also aiming to ultimately Create artificial cells from the bottom up.
Cees Dekker is Distinguished University Professor at TU Delft. Educated as being a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes inside the 1990s. Because 2000, he moved to single-molecule biophysics and nanobiology. His current research concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, specifically SMC motor protein; and (iii) building a living synthetic mobile from lifeless molecules. Dekker can be an elected member with the KNAW and fellow to your APS plus the IOP.
2008, initial observation of protein-coated DNA translocation via nanopores; resolved the origin of the electrophoretic drive on DNA in nanopores; found out an important velocity raise of microtubules in electrical fields; uncovered an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid
2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental examine of ions conduction in nanofluidic channels; initial electrochemistry with unique solitary-wall carbon nanotubes; STM detection and Charge of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; very first biophysics characterization of your mechanical Homes of double-stranded RNA; and first solitary-molecule study of DNA translocation by a restriction-modification enzyme.